Immunotherapy + Immunotherapy

Immunotherapy + Immunotherapy


Simultaneously inhibiting the CTLA-4 and PD-L1 non-redundant pathways has potential for synergistic immune effects4-7*

Immunotherapy + Immunotherapy Combination Therapy Immunotherapy + Immunotherapy Combination Therapy The major histocompatibility complex (MHC) on tumor cells must also present antigens to T-cell receptors to activate T cells10


CTLA-4 pathway inhibition enhances T-cell activation, amplifies T-cell proliferation, and promotes differentiation into memory T cells7-9,11-13

Learn more about how CTLA-4 pathway inhibition enhances antitumor response


PD-L1 pathway inhibition reverses T-cell exhaustion and reinvigorates antitumor activity11,15,17-20

PD-L1 blockade also increases the availability of ligands for the co-stimulatory pathway (CD80, CD86) in the lymph node, thereby enhancing T-cell activation and proliferation.

Learn more about PD-L1 pathway inhibition


CTLA-4 and PD-L1 both bind to CD80 (B7.1): Simultaneous inhibition of both pathways may lead to synergistic effects on antitumor activity4,5,19,21

TAKE A DEEPER LOOKat the science of combination immuno-oncology therapy

Combination strategies are a key area of clinical research because they have the potential to simultaneously inhibit complementary immunosuppressive pathways.

PD-L1=programmed cell death ligand-1; CTLA-4=cytotoxic T-lymphocyte-associated antigen-4.


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